Eric Gaucher, Associate Professor
Ph.D., Evolutionary & Biomedical Sciences, University of Florida, 2001
Phone: 404-385-3265
Fax: 404-894-0519
Office: Cherry Emerson 311
Publications
Johnson, R. J., Gaucher, E. A., Sautin, Y. Y., Henderson, G. N., Angerhofer, A. J., and S. A. Benner (2008). The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease. Med Hypotheses. 71:22-31.
Gaucher, E. A., Ganesh, O. & S. Govindarajan (2008). Paleotemperature trend for Precambrian life inferred from resurrected proteins. Nature, 451: 704-707.
Gaucher, E. A. (2007). Ancestral sequence reconstruction as a tool to understand natural history and guide synthetic biology: Realizing (and extending) the vision of Zukerkandl and Pauling. in Ancestral Sequence Reconstruction pp. 20-33 (Ed. David Liberles, Oxford University Press).
Gaucher, E. A. (2007). Experimental resurrection of ancient biomolecules: gene synthesis, heterologous protein expression, and functional assays. in Ancestral Sequence Reconstruction pp.153-163 (Ed. David Liberles, Oxford University Press).
Danchin, E. G. J., Gaucher, E. A., P. Pontarotti (2007). Computational reconstruction of ancestral genomic regions from evolutionarily conserved gene clusters. in Ancestral Sequence Reconstruction pp. 139-152 (Ed. David Liberles, Oxford University Press).
Brooks, D. J. and Gaucher, E. A. (2007). Inferred thermophily of the last universal ancestor based on estimated amino acid composition. in Ancestral Sequence Reconstruction pp. 200-207 (Ed. David Liberles, Oxford University Press).
Benner, S. A., Sassi, S., and E. A. Gaucher (2007). Molecular Paleoscience. Systems Biology from the Past. Adv. Enzymol. Relat. Areas Mol. Biol. 75:1-132.
Gaucher, E. A., De Kee, D. W., and S. A. Benner (2006) Application of DETECTER, an evolutionary genomic tool to analyze genetic variation, to the cystic fibrosis gene family. BMC Genomics 7:44.
Li, T., Chamberlin, S. G., Caraco M. D., Gaucher, E. A., Liberles, D. A., and S. A. Benner (2006). Transition redundant approach-to-equilibrium analysis of gene sequences: Tools to date events in the genomic record. BMC Evol. Biol. 6:25.
Phillips, S. E., Vincent, P., Rizzieri, K. E., Schaaf, G., Bankaitis, V. A., and E. A. Gaucher (2006). The diverse biological functions of phosphatidylinositol transfer proteins in eukaryotes. Crit. Rev. Biochem. Mol. Biol. 41:21-49.
Gaucher, E. A. and M. Miyamoto (2005). A call for likelihood phylogenetics even when evolution is heterogeneous. Molecular Phylogenetics & Evolution 37:928-931.
Thomson, J. M., Gaucher, E. A., Burgan, M. F., Li, T., Aris, J. P. and S. A. Benner (2005). Resurrecting ancient alcohol dehydrogenases from Yeast. Nature Genetics 37:630-635.
Gaucher, E. A., Graddy, L. G., Simmen, R. C. M., Simmen, F. A., Kowalski, A. A., Schreiber, D. R., Liberles, D. A., Zhao, G., Janis, C. M. and S. A. Benner (2004). The planetary biology of aromatases in pigs. BMC Biology. 2(1):19.
West, C. M., Van Der Wel, H., Sassi, S. and E. A. Gaucher. Cytoplasmic glycosylation of protein-hydroxyproline and its relationship to other glycosylation pathways. Biochim. Biophys. Acta. 1673:29-44.
Gaucher, E. A., Burgan, M. F., Thomson, J. M. and S. A. Benner (2003). Inferring the paleoenvironment of ancient bacteria based on resurrected ancestral proteins. Nature 425:285-288.
Gaucher, E. A., Miyamoto, M. M. and S. A. Benner (2003). Evolutionary, structural and biochemical evidence for a new interaction site of the leptin obesity protein. Genetics 163:1549-1553.
Gaucher, E. A, Gu, X., Miyamoto, M. M. and S. A. Benner (2002). Predicting functional divergence in protein evolution by site-specific rate shifts. Trends Biochem. Sci. 27:315-321.
Benner, S. A., Caraco, M. D., Thomson, J. M. and E. A. Gaucher (2002). Planetary biology - paleontological, geological, and molecular histories of life. Science 296:864-868.
West, C. M., van der Wel, H. and E.A. Gaucher (2002). Complex glycosylation of Skp1 in Dictyostelium: implications for the modification of other eukaryotic cytoplasmic and nuclear proteins. Glycobiology 12:17R-27R.
Gaucher, E. A., Das, U. K., Miyamoto, M. M. and S. A. Benner (2002). The Crystal Structure of eEF1A Supports the Functional Predictions of an Evolutionary Analysis of Rate Changes among Elongation Factors. Mol. Biol. Evol. 19:569-573.
Benner, S. A. and E. A. Gaucher (2001). Evolution, language and analogy in functional genomics. Trends Genet. 17:414-418.
Gaucher, E. A., Miyamoto, M. M. and S. A. Benner (2001). Function-structure analysis of proteins using covarion-based evolutionary approaches: Elongation factors. Proc. Nat. Acad. Sci. 98:548-552.
Laten, H. M., Majumdar, A. and E. A. Gaucher (1998). SIRE-1, a copia/Ty1-like retroelement from soybean, encodes a retroviral envelope-like protein. Proc. Nat. Acad. Sci. 95:6897-6902.