Biology

Julia Kubanek, Associate Professor

Ph.D., Organic Chemistry, University of British Columbia, 1998
julia.kubanek@biology.gatech.edu
Phone: (404) 894-8424
Fax: (404) 385-4440
Office: Enviormental Science & Technology 2242/2170, 2172, 2175

Publications

Refereed Publications:
  *indicates corresponding authorship
  # indicates current or former Kubanek students/postdocs

(a) Accepted for Publication:

43. Lane AL#, Stout EP#, Hay ME, Prusak AC#, Hardcastle K, Fairchild CR, Aalbersberg W, Kubanek J* (2007) Callophycoic acids and callophycols from the Fijian red alga Callophycus serratus.  Manuscript accepted by Journal of Organic Chemistry.

42. Lane AL#, Kubanek J* (2007) Secondary metabolite defenses against pathogens and biofoulers.  Invited review in press Algal Chemical Ecology (peer-reviewed book edited by C. Amsler).

41. Kubanek J*, Snell TW (2007) Quorum sensing in rotifers.  Invited review accepted by Chemical Communication Among Microbes (peer-reviewed book edited by S.C. Winans and B.L. Bassler).

(b) Already Published:

40. Kubanek J*, Snell TW, Pirkle C# (2007) Chemical defense of the red tide dinoflagellate Karenia brevis against rotifer grazing.  Limnology & Oceanography 52:1026-1035

39.  Parker JD, Burkepile DE, Collins DO#, Kubanek J, Hay ME (2007) Stream mosses as chemically-defended refugia for freshwater macroinvertebrates.  OIKOS 116:302-312

38.  Prince EK#, Lettieri L#, McCurdy KJ#, Kubanek J* (2006) Fitness consequences for copepods feeding on a red tide dinoflagellate: deciphering the effects of nutritional value, toxicity, and feeding behavior. Oecologia 147:479-488

37.  Lane AL#, Kubanek J* (2006) Structure-activity relationship of chemical defenses from the freshwater plant Micranthemum umbrosum.  Phytochemistry 67:1224-1231

36.  Kubanek J*, Prusak AC#, Snell TW, Giese RA#, Fairchild CR, Aalbersberg W, Hay ME (2006)  Bromophycolides C-I from the Fijian red alga Callophycus serratus.  Journal of Natural Products 69:731-735

35.  Burkepile DE, Parker JD, Woodson CB, Mills HJ, Kubanek J, Sobecky P, Hay ME (2006)  Chemically-mediated competition between microbes and animals: microbes as consumers in food webs. Ecology 87:2821-2831

34.  Snell TW, Kubanek J, Carter W, Payne AB, Kim J, Hicks MK#, Stelzer CP (2006) A protein signal triggers sexual reproduction in Brachionus plicatilis (Rotifera). Marine Biology 149:763-773

33.  Parker JD, Collins DO#, Kubanek J, Sullards MC, Bostwick D, Hay ME (2006) Chemical defenses promote persistence of the aquatic plant Micranthemum umbrosum.  Journal of Chemical Ecology 32:815-833

32.  Kubanek J*, Prusak AC#, Snell TW, Giese RA#, Hardcastle K, Fairchild C, Aalbersberg W, Raventos-Suarez C, Hay ME (2005) Antineoplastic diterpene-benzoate macrolides from the Fijian red alga Callophycus serratus.  Organic Letters 7:5261-5264

31. Kubanek J*, Prusak AC#, Snell TW, Giese RA#, Hardcastle K, Fairchild C, Aalbersberg W, Raventos-Suarez C, Hay ME (2005) Antineoplastic diterpene-benzoate macrolides from the Fijian red alga Callophycus serratus. Organic Letters 7:5261-5264

30. Kubanek J*, Hicks MK#, Naar J, Villareal T (2005) Does the red tide dinoflagellate Karenia brevis use allelopathy to out-compete other phytoplankton? Limnology and Oceanography 50: 883-895

29. Prusak AC#, O'Neal J#, Kubanek J* (2005) Prevalence of chemical defenses in freshwater macrophytes. Journal of Chemical Ecology 31:1145-1160

28. Barsby, T, Kubanek J* (2005) Isolation and structure elucidation of feeding deterrent diterpenoids from the sea pansy Renilla reniformis. Journal of Natural Products 68:511-516

27. John EA#, Pollet P, Gelbaum L, Kubanek J* (2004) Synthesis and antifeedant effect of 2,3,4-tribromopyrrole. Journal of Natural Products 67:1929-1931

26. Kubanek, J., Lester S., Fenical W., Hay M.E. (2004) Ambiguous roles of phlorotannins as chemical defenses in the brown algaa Fucus vesiculous. Marine Ecology Progress Series 277:79-93.

25. Kicklighter, C., Kubanek, J., Hay M.E. (2004) Do brominated natural products defend marine worms from consumer? Some do, most don't. Limnology and Oceanography 49:430-441.

24. Fuller MD, Zhang ZR, Cui G, Kubanek J, McCarty NA (2004) Inhibition of CFTR channels by a peptide toxin of scorpion venom. American Journal of Physiology - Cell Physiology 287:C1328-C1341

23. Naar J, Kubanek J, Weidner A, Flewelling L, Bourdelais AJ, Steidinger, K, Baden DG (2004) Brevetoxin depuration in shellfish via production of non-toxic metabolites: Consequences for seafood safety and the environmental fate of biotoxins. In: Steidinger KA, Landsberg JH, Tomas CR, Vargo GA (eds). Harmful Algae 2002: Proceedings of the Xth International Conference pp 488-490

22. Bourdelais AJ, Campbell S, Benson J, Abraham WM, Naar J, Kubanek J, Wright JLC, Jacocks H, Baden DG (2004) FloridaÕs red tide dinoflagellate Karenia brevis may modulate its potency by producing a non-toxic competitive antagonist. In: Steidinger KA, Landsberg JH, Tomas CR, Vargo GA (eds). Harmful Algae 2002: Proceedings of the Xth International Conference pp 113-115

21. Kubanek J, Jensen PR, Keifer PA, Sullards C, Collins DO#, Fenical W (2003) Seaweed resistance to microbial attack: A targeted chemical defense against marine fungi. Proceedings of the National Academy of Sciences USA 100: 6916-6921

20. Barsby T, Kicklighter, C, Hay ME, Sullards MC, Kubanek J* (2003) Defensive 2-alkylpyrrole sulfamates from the marine annelid Cirriformia tentaculata [Polychaeta: Cirratulidae]. Journal of Natural Products 66:1110-1112

19. Kicklighter C, Kubanek J, Barsby T, Hay ME (2003) Palatability and defense of some tropical marine worms: Alykylpyrrole sulfamates as deterrents to fish feeding. Marine Ecology Progress Series 263:299-306

18. Taylor RB, Lindquist N, Kubanek J, Hay ME (2003) Intraspecific variation in palatability and defensive chemistry of brown seaweeds: effects on herbivore fitness. Oecologia

17. Kubanek J*, Whalen KE#, Engel S, Kelly SR, Henkel TP, Fenical W, Pawlik JR (2002) Multiple defensive roles for triterpene glycosides from two Caribbean sponges. Oecologia 131:125-136

16. Hay ME, Kubanek J (2002) Community and ecosystem level consequences of chemical signaling in the plankton. Journal of Chemical Ecology 28:2001-2016

15. Bourdelais AJ, Tomas CR, Naar J, Kubanek J, Baden DG (2002) New fish-killing alga in coastal Delaware produces neurotoxins. Environmental Health Perspectives 110:465:470

14. Naar J, Bourdelais A, Tomas CR, Kubanek J, Whitney PL, Flewelling L, Steidinger K, Lancaster J, Baden DG (2002) A competitive ELISA to detect brevetoxin from Karenia brevis (formerly Gymnodinium breve) in seawater, shellfish, and mammalian body fluid. Environmental Health Perspectives 110:179-186

13. Kubanek J*, Fenical W, Pawlik JR (2001) New antifeedant triterpene glycosides from the Caribbean sponge Erylus formosus. Natural Product Letters 15:275-285

12. Kubanek J, Hay ME, Brown PJ, Lindquist N, Fenical W (2001) Lignoid chemical defenses in the freshwater macrophyte Saururus cernuus. Chemoecology 11:1-8

11. Kubanek J, Pawlik JR, Eve TM, Fenical W (2000) Triterpene glycosides defend the Caribbean reef sponge Erylus formosus from predatory fishes. Marine Ecology Progress Series 207:69-77

10. Kubanek J*, Fenical W, Hay ME, Brown PJ, Lindquist N (2000) Two new antifeedant lignans from the freshwater macrophyte Saururus cernuus. Phytochemistry 54:281-287

9. Kubanek J, Faulkner DJ, Andersen RJ (2000) Geographic variation and tissue distribution of endogenous terpenoids in the Northeastern Pacific Ocean dorid nudibranch Cadlina luteomarginata.: implications for the regulation of de novo biosynthesis. Journal of Chemical Ecology 26:377-389

8. Kubanek J, Andersen RJ (1999) Evidence for de novo biosynthesis of the polyketide fragment of diaulusterol A by the Northeastern Pacific dorid nudibranch Diaulula sandiegensis, Journal of Natural Products 62:777-779

7. Ohba M, Nishimura Y, Imasho M, Fujii T, Kubanek J, Andersen RJ (1998) Chiral synthesis of tri-O-methylimbricatine, an etherified derivative of the starfish alkaloid imbricatine. Tetrahedron Letters 39:5999-6002

6. Kubanek J, Graziani EI, Andersen RJ (1997) Investigations of terpenoid biosynthesis by the dorid nudibranch Cadlina luteomarginata. Journal of Organic Chemistry 62:7239-7246

5. Kubanek J, Andersen RJ (1997) Evidence for the incorporation of intact butyrate units in the biosynthesis of triophamine. Tetrahedron Letters 38:6327-6330

4. Dumdei EJ, Kubanek J, Coleman JE, Pika J, Andersen RJ, Steiner JR, Clardy J (1997) New terpenoid metabolites from the skin extracts, an egg mass, and dietary sponges of the Northeastern Pacific dorid nudibranch Cadlina luteomarginata. Canadian Journal of Chemistry 75: 773-789

3. Kubanek J, Williams DE, de Silva ED, Allen T, Andersen RJ (1995) Cytotoxic alkaloids from the flatworm Prostheceraeus villatus and its tunicate prey Clavelina lepadiformis. Tetrahedron Letters 36:6189-6192

2. Bikker JA, Kubanek J, Weaver D (1994) Quantum pharmacologic studies applicable to the design of anti-convulsants: theoretical conformational analysis and structure-activity studies of barbiturates. Epilepsia 35:411-425

1. Davis JM, Cameron DR, Kubanek J, Mizuyabu L, Thatcher GRJ (1991) Acceleration of sulfate ester hydrolysis in hydrophobic environments. Tetrahedron Letters 32:2205-2206

(c) In preparation:

Prince EK#, Myers TL, Kubanek J*.  Effects of harmful algal blooms on competitors: allelopathic mechanisms of the red tide dinoflagellate Karenia brevis. Manuscript submitted to Limnology & Oceanography

Fuller MD, Thompson CH, Zhang ZR, McMaster D, French RJ, Pohl J, Kubanek J, McCarty NA. Inhibition of CFTR chloride channels by a novel peptide toxin.  Manuscript submitted to Proceedings of the National Academy of Sciences USA.

Padove SA, Hatt H, Kubanek J, McCarty NA. Reconstitution of a chemical defense signaling pathway in a heterologous system.  Manuscript submitted to Journal of Experimental Biology.

Thompson CH, Olivetti PR, Fuller MD, McMaster D, French RJ, Pohl J, Kubanek J, McCarty NA. Isolation of a novel peptide inhibitor of ClC-2 chloride channels.  Manuscript submitted to Proceedings of the National Academy of Sciences USA.

Myers TL, Prince EK#, Naar J, Kubanek J*.  Competition among phytoplankton leads to loss of waterborne brevetoxins.

Jiang RW#, Mylacraine L, Lane AL#, Hay ME, Hardcastle K, Kubanek J*. Molecular structure and absolute configuration of sulfate conjugated triterpenoids: chemical defensive agents from the marine green alga Tydemania expeditionis.

Non-Refereed Publications:

(a) Already published:

Kubanek J (2003) Chemical defense in invertebrates. In Encyclopedia of Life Support Systems, Section: Chemical Ecology, edited by JD Hardege, developed under the auspices of UNESCO, EOLSS Publishers, Oxford UK http://www.eolss.net