King Jordan, Associate Professor
Ph.D., Genetics, University of Georgia, 1998
Phone: 404-385-2224
Fax: 404-894-0519
Office: (Cherry Emerson) 215
Research Interests
Bioinformatics, Molecular Evolution, and Evolutionary Genomics
Overview
My research program is focused on understanding the genome level determinants of the diversification between evolutionary lineages. The approach that I use towards this end is computationally based and consists of the comparative analysis of large-scale genomic sequence, expression and functional data sets. This approach is facilitated by the accumulation of genome-scale data sets and the continuing development of the computational applications and infrastructure needed to exploit such data. Ultimately, I hope to integrate our understanding of how evolutionary forces play out at distinct levels of biological organization.
More specifically, I am interested in understanding the nature of evolutionary innovations that have led to the emergence of complexity in eukaryotic lineages. I currently explore three distinct research areas relating to the evolution of eukaryotic genome complexity: i-the contributions of transposable elements to host gene regulatory and protein coding sequences, ii-the tempo and mode of gene regulatory and expression divergence and iii-convergent evolution of gene function.Selected Publications
Mariño-Ramírez, L. and I.K. Jordan, 2006. Transposable element derived DNaseI-hypersensitive sites in the human genome. Biol. Direct. 1:20
Jordan, I.K, 2006. Evolutionary tinkering with transposable elements. Proc. Natl. Acad. Sci. USA 103:7941-7942
Mariño-Ramírez, L., Lewis, K.C., Landsman, D. and I.K. Jordan, 2005. Transposable elements donate lineage-specific regulatory elements to host genomes. Cytogenet. Genome Res. 110: 333-341
Jordan, I.K., Mariño-Ramírez, L. and E.V. Koonin, 2005. Evolutionary significance of gene expression divergence. Gene 345: 119-126
Jordan, I.K., Kondrashov F.A., Adzhubei I.A., Wolf Y.I., Koonin E.V., Kondrashov A.S. and S. Sunyaev, 2005. A universal trend of amino acid gain and loss in protein evolution. Nature 433: 633-638
Jordan, I.K., Mariño-Ramírez, L., W olf, Y.I. and E.V. Koonin, 2004. Conservation and co-evolution in the scale-free human gene coexpression network. Mol. Biol. Evol. 21: 2058-2070
Jordan, I.K., Rogozin I.B., Glazko G.V. and E.V. Koonin, 2003. Origin of a substantial fraction of human regulatory sequences from transposable elements. Trends Genet. 19: 68-72