Mark Borodovsky, Regents' Professor, Director Center for the Bioinformatics and Computational Genomics
Ph.D., Applied Mathematics, Moscow Institute of Physics and Technology, 1976
Phone: (404) 894-8432
Fax: (404) 894-0519
Office: 301 at Cherry Emerson
Research Interests
Research focus of the lab is on computational analysis of biological sequences with the goal of identifying functionally important features of DNA and proteins. Our primary interest is on genes, regulatory sites, mobile elements, evolutionary conserved protein domains. Given the statistical nature of biological sequence evolution we develop new algorithms using probabilistic models (http://opal.biology.gatech.edu/GeneMark/).
Long term collaboration with experimental molecular biologists and several genome sequencing groups has advanced our understanding of how little we actually know about complexity of the cellular machines driven by genetic design. We develop algorithms reducing this uncertainty by most probable reconstruction of the whole from a few randomly observed pieces.
Prospective graduate students should apply to the Georgia Tech PhD program in Bioinformatics with the home either at the School of Biology or at the Department of Biomedical Engineering.
Prospective postdocs should contact us directly, sending a CV, contact information for three references, and a statement of research interests.
Selected Publications
[Complete list of publications]Lomsadze A., Ter-Hovhannisyan V., Chernoff Y. and M. Borodovsky (2005) Gene identification in novel eukaryotic genomes by self-training algorithm, Nucleic Acids Research, 33: 6494-6506
Mitrophanov, A. Yu., Lomsadze, A. and Borodovsky, M. (2005) Sensitivity of hidden Markov models. J. Appl. Probab., 42: 632Ð642
Besemer J. and M. Borodovsky (2005) GeneMark: web software for gene finding in prokaryotes, eukaryotes and viruses, Nucleic Acids Research, 33, Web Server issue, W451ÐW454
Kattenhorn L., Mills R., Vagner M., Lomsadze A., Makeev V., Borodovsky M. Ploeh H. Kessler B., (2004) Identification of Proteins Associated with Murine Cytomegalovirus Virion, J of Virology, 78, 11187-11197
Small TM., Flaherty DB., Gernet KM., M. Borodovsky & G. Benian (2004) A new isoform of C. elegans UNC-89 containing two MLCK-like protein kinase domains, J. Mol. Biol. 342, 91-108
