Biology

Nael McCarty, Associate Professor

Ph.D., Cell Physiology, UT Health Science Center-Houston, 1990
nael.mccarty@biology.gatech.edu
Phone: (404) 385-2955
Fax: (404) 894-0519
Office: (Cherry Emerson) 223/230

Publications

McCarty, N.A. and R.G. O’Neil (1990) Dihydropyridine-sensitive cell volume regulation in renal proximal tubule: the calcium window. Am. J. Physiol. 259:F950-F960.

McCarty, N.A. and R.G. O’Neil (1991) Calcium-dependent control of volume regulation in renal proximal tubule cells. I. Swelling-activated Ca2+ entry and release. J. Membr. Biol. 123:149-160.

McCarty, N.A. and R.G. O’Neil (1991) Calcium-dependent control of volume regulation in renal proximal tubule cells. II. Roles of dihydropyridine-sensitive and -insensitive Ca2+ entry pathways. J. Membr. Biol. 123:161-170.

Kahn, A.M., E.J. Cragoe, Jr., J.C. Allen, C.L. Seidel, S.S. Navran, R.G. O’Neil, N.A. McCarty, and H. Shelat (1992) Effects of serotonin on intracellular pH and contraction in vascular smooth muscle. Circ. Res. 71:1294-1304.

McCarty, N.A., S. McDonough, B.N. Cohen, J.R. Riordan, N. Davidson, and H. Lester (1993) Voltage-dependent blockade of the cystic fibrosis transmembrane conductance regulator by two closely related arylaminobenzoates. J. Gen. Physiol. 102:1-23.

Uezono, Y., J. Bradley, C. Min, N.A. McCarty, M. Quick, JR. Riordan, C. Chavkin, K. G. Zinn, H. A. Lester, and N. Davidson (1993) Receptors that couple to 2 classes of G proteins increase cAMP and activate CFTR expressed in Xenopus oocytes. Receptors Channels 1:233-241.

McDonough, S., N. Davidson, H.A. Lester, and N.A. McCarty (1994) Novel pore-lining residues in CFTR that govern permeation and open channel block. Neuron 13:623-634.

Walker, L., C.J. Venglarik, G. Aubin, M. Weatherly, N.A. McCarty, B. Lesnick, F. Ruiz, J.P. Clancy, and E.J. Sorscher (1997) Relationship between airway ion transport and a mild pulmonary disease mutation in CFTR. Am. J. Respir. Crit. Care Med 155: 1684-1689.

Zhang, Z.-R., S. Zeltwanger, and N.A. McCarty (2000) Direct comparison of NPPB and DPC as probes of CFTR expressed in Xenopus oocytes. J.Membr. Biol. 175: 35-52.

Zhang, Z.-R., S. I. McDonough, and N.A. McCarty (2000) Interaction between permeation and gating in a putative pore-domain mutant in CFTR. Biophys. J. 79: 298-213.

Zhang, Z.-R., S. Zeltwanger, S.S. Smith, D.C. Dawson, and N.A. McCarty (2002). Voltage-sensitive gating induced by a mutation in the fifth transmembrane domain mutant of CFTR. Am. J. Physiol., Lung 282:L135-L145.

Smith, S.S., F. Sun, T.E. Kriewall, Z.-R. Zhang, N.A. McCarty, and D.C. Dawson (2001) CFTR: Covalent and non-covalent modification suggests a role for fixed charges in anion conduction. J. Gen. Physiol. 118:407-431.

McCarty, N.A., and Z.-R. Zhang (2001) Identification of a region of strong discrimination in the pore of CFTR. Am. J. Physiol., Lung 281:L852-L867.

N.A. McCarty, T.A. Standaert, M. Teresi, C. Tuthill, J. Launspach, T.J. Kelly, L.J.H. Milgram, K.A. Hilliard, W.E. Regelmann, M.R. Weatherly, M. L. Aitken, M. W. Konstan, and R.C. Ahrens (2002) A phase I trial of CPX in adult patients with mild cystic fibrosis. Ped. Pulmonol. 33:90-98.

R.C. Ahrens, T.A. Standaert, J. Launspach, S.-H. Han, M.E. Teresi, M.L. Aitken, T.H. Kelly, K.A. Hilliard, L.J.H. Milgram, M.W. Konstan, M.R. Weatherly, and N.A. McCarty (2002) Variability of outcome measures in multicenter clinical trials for cystic fibrosis. Ped. Pulmonol. 33:142-150.

Zhang, Z.-R., S. Zeltwanger, S. S. Smith, D. C. Dawson, and N. A. McCarty (2002) Voltage-sensitive gating induced by a mutation in the fifth transmembrane domain of CFTR. Am. J. Physiol. 282:L852-L867.

Manuscripts submitted:

Zhang, Z.-R., Zeltwanger, S., and N.A. McCarty. Analysis of glibenclamide interaction with CFTR: evidence for multiple sites of inhibition. Biophys. J. (in revision)

Zhang, Z.-R., S. Zeltwanger, and N.A. McCarty. Time-dependent block by glibenclamide and DPC probe the wide cytoplasmic vestibule of CFTR. Biophys. J. (in revision)