Biology

Tsai-Tien Tseng, Graduate Coordinator & Academic Professional

Ph.D., Biophysics and Computational Biology, University of Illinois at Urbana-Champaign
M.S., Biology, University of California, San Diego
B.S., Molecular Biology, University of California, San Diego

Phone: 404-385-4240
Fax: 404-894-0519
Office: 209 Cherry Emerson

Biography

Tsai-Tien Tseng completed his Ph.D. dissertation, titled "Molecular Archeology of Voltage-gated Ion Channels," at the University of Illinois at Urbana-Champaign. His Ph.D. work focused on the molecular phylogeny of the Voltage-gated Ion Channel (VIC) superfamily and various auxiliary subunits. He received the Molecular Biophysics Training Grant from the National Institute of Health for his dissertation work.

Research Interest

Tsai-Tien is interested in the molecular evolution and classification of various membrane transporter families and superfamilies. He has previously characterized the Major Facilitator Superfamily (MFS) and the Resistance-Nodulation-Cell Division (RND) superfamily. His work also included literature-based bacterial genome annotation using Gene Ontology terms.

Selected Publications

JOURNAL ARTICLES

Chibucos, M.C.*, Tseng, T.-T.*, Setubal, J.C. (2009) Describing commonalities in microbial effector delivery using the Gene Ontology. Trends in Microbiology (in press) *These authors contributed equally.

Tseng, T.-T.*, Tyler, B.M.*, Setubal, J.C.* (2009) Protein Secretion Systems in Bacterial-Host Associations, and their Description in the Gene Ontology. BMC Microbiology 9(Suppl 1):S2 *These authors contributed equally.

Tseng, T.-T., McMahon, A.M., Johnson, V.T., Mangubat, E.Z., Zahm, R.J., Pacold, M.E., and Jakobsson, E. (2007) Sodium channel auxiliary subunits. J Mol Microbiol Biotechnol 12(3-4):249-62

Kang, J., and Tseng, T.-T. (2007) Analysis of S-adenosylmethionine binding to Afsk, a protein kinase from Streptomyces coelicolor. FEMS Microbiology Letters Jun;271(1):1-2.

Tseng, T.-T., McMahon, A.M., Mangubat, E.Z., Zahm, R.J., Pacold, M.E., and Jakobsson, E. (2006) Calcium channel auxiliary subunits. J Mol Microbiol Biotechnol 11(6):326-44.

Mangubat, E.Z., Tseng, T.-T., and Jakobsson, E. (2003) Phylogenetic analyses of potassium channel auxiliary subunits. J Mol Microbiol Biotechnol 5: 216-224. (EZM and TTT contributed equally)

Harley, K.T., Djordjevic, G.M., Tseng, T.-T., and Saier, M.H. (2000) Membrane-fusion protein homologues in gram-positive bacteria. Mol Microbiol 36: 516-517.

Tseng, T.-T., Gratwick, K.S., Kollman, J., Park, D., Nies, D.H., Goffeau, A., and Saier, M.H., Jr. (1999) The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins. J Mol Microbiol Biotechnol 1: 107-125.

Saier, M.H., Jr., Eng, B.H., Fard, S., Garg, J., Haggerty, D.A., Hutchinson, W.J., Jack, D.L., Lai, E.C., Liu, H.J., Nusinew, D.P., Omar, A.M., Pao, S.S., Paulsen, I.T., Quan, J.A., Sliwinski, M., Tseng, T.-T., Wachi, S., and Young, G.B. (1999) Phylogenetic characterization of novel transport protein families revealed by genome analyses. Biochim Biophys Acta 1422: 1-56.

Saier, M.H., Jr., Beatty, J.T., Goffeau, A., Harley, K.T., Heijne, W.H., Huang, S.C., Jack, D.L., Jahn, P.S., Lew, K., Liu, J., Pao, S.S., Paulsen, I.T., Tseng, T.-T., and Virk, P.S. (1999) The major facilitator superfamily. J Mol Microbiol Biotechnol 1: 257-279.

Le, T., Tseng, T.-T., and Saier, M.H., Jr. (1999) Flexible programs for the prediction of average amphipathicity of multiply aligned homologous proteins: application to integral membrane transport proteins. Mol Membr Biol 16: 173-179. (TL and TTT contributed equally)

Chang, K.H., Wen, F.S., Tseng, T.-T., Lin, N.T., Yang, M.T., and Tseng, Y.H. (1998) Sequence analysis and expression of the filamentous phage phi Lf gene I encoding a 48-kDa protein associated with host cell membrane. Biochem Biophys Res Commun 245: 313-318.

Liu, T.J., Wen, F.S., Tseng, T.-T., Yang, M.T., Lin, N.T., and Tseng, Y.H. (1997) Identification of gene VI of filamentous phage phi Lf coding for a 10-kDa minor coat protein. Biochem Biophys Res Commun 239: 752-755.

BOOK CHAPTERS

Jakobsson, E., Mashl, R.J., and Tseng, T.-T. (2002) Investigating ion channels using computational methods. Peptide-lipid interactions (Current Topics in Membranes, Vol 52). (2002) (All authors contributed equally)

Saier, M.H. Jr., and Tseng, T.-T. (1999) Evolutionary origins of transmembrane transport systems. Transport of molecules across microbial membranes. Symposium 58. Society for General Microbiology