Biology

Yury Chernoff, Professor

Ph.D.,Biology, St. Petersburg State University (Russia), 1985
yury.chernoff@biology.gatech.edu
Phone: (404) 894-1157
Fax: (404) 894-0519
Office: IBB 2304, 2230

Publications

Chen, B., G.P. Newnam and Y.O. Chernoff (2007) Prion species barrier between the closely related yeast proteins is detected despite coaggregation. Proc. Natl. Acad. Sci. USA 104: 2791-2796. (Abstract)

Allen, K.D., T.A. Chernova, E.P. Tennant, K.D. Wilkinson and Y.O. Chernoff (2007) Effects of the ubiquitin system alterations on the de novo formation and loss of a yeast prion. Journal of Biological Chemistry 282: 3004-3013 (JBC Paper of the Week). (Abstract)

Meriin, A.B., X. Zhang, I.M. Alexandrov, A.B. Salnikova, M.D. Ter-Avanesyan, Y.O. Chernoff and M.Y. Sherman (2007) Endocytosis machinery is involved in aggregation of proteins with expanded polyglutamine domains. FASEB J. 21:1915-1925.

Borchsenius A.S., S. Muller, G.P. Newnam, S.G. Inge-Vechtomov and Y.O. Chernoff (2006) Prion variant maintained only at high levels of the Hsp104 disaggregase. Curr. Genet. 49: 21-29. (Abstract)

Ganusova, E.E., L.N. Ozolins, S. Bhagat, G.P. Newnam, R.D. Wegrzyn, M.Y. Sherman and Y.O. Chernoff (2006) Modulation of prion formation, aggregation and toxicity by the actin cytoskeleton in yeast. Mol. Cell. Biol. 26: 617-629.(Abstract)

Lomsadze, A., V. Ter-Hovhannisyan, Y.O. Chernoff and M. Borodovsky (2005) Gene identification in novel eukaryotic genomes by self-training algorithm. Nucleic Acids Res. 33: 6494-6506.

Ono, B., Futase,T., Honda, W. , Yoshida, R., Nakano, K. Yamamoto, T., Nakajima, E., Noskov, V.N., Negishi, K., Chen, B. and   Chernoff, Y.O. (2005) The Saccharomyces cerevisiae ESU1 gene, that is responsible for enhancement of termination suppression, corresponds to the 3'-terminal half of GAL11. Yeast 22: 895-906.

Gokhale, K.C., Newnam,G.P., Sherman, M.Y. and Chernoff, Y.O. (2005) modulation of prion-dependent polyglutamine aggregation and toxicity by chaperone proteins in the yeast model. Journal of Biological Chemistry 280: 22809-22818. (Abstract)

Allen, K.D., Wegrzyn, R.D., Chernova, T.A., Muller, S., Newnam, G.P., Winslett, P.A., Wittich, K.B., Wilkinson, K.D. and Chernoff, Y.O. (2005) Hsp70 chaperones as modulators of prion life cycle: novel effects of Ssa and Ssb on the Saccharomyces cerevisiae prion [PSI+ ]. Genetics 169: 1227-1242. [Epub ahead of print 2004]. (Abstract)

Chernoff, Y.O. (2004) Amyloidogenic domains, prions and structural inheritance: rudiments of early life or recent acquisition? Current Opinion in Chemical Biology , 8: 665-671. (Abstract)

Chernoff, Y.O. (2004) Replication vehicles of protein-based inheritance. Trends in Biotechnology 22: 549-552.

Chernoff, Y.O. (2004) Cellular Control of Prion Formation and Propagation in Yeast. In: Prions and Prion Diseases: Current Perspectives (Telling, G. ed.), Horizon Scientific Press, pp. 257-303.

Chernova, T.A., Allen, K.D.,Wesoloski, L.M., Shanks, J.R., Chernoff, Y.O. and Wilkinson, K.D. (2003) Pleiotropic effects of Ubp6 loss on drug sensitivities and yeast prion are due to depletion of free ubiquitin pool. Journal of Biological Chemistry , 278: 52102-52115. (Abstract)

  Meriin, A.B., Zhang, X., Miliaras, N.B., Kazantsev, A., Chernoff, Y.O., McCaffery, J.M., Wendland, B. and Sherman, M.Y.   (2003) Aggregation of expanded polyglutamine domain in yeast leads to defects in endocytosis. Molecular and Cellular Biology , 23: 7554-7565.

Zhouravleva, G.A., Alenin, V.V., Inge-Vechtomov, S.G. and Chernoff, Y.O. (2002) To stick or not to stick: prion domains from yeast to mammals. In: Recent Research Developments in Molecular and Cellular Biology . Research Signpost, India. Vol. 3, Part 1 (Pandalai, S.G., ed.), pp. 185-218.

Chernoff, Y.O. , Uptain, S.M. and Lindquist, S.L. (2002) Analysis of prion factors in yeast. In: In: Guide to Yeast Genetics and Molecular and Cell Biology , Parts B and C (Guthrie, C. and G.R. Fink, eds.).  Methods in Enzymology 351: 499-538.

Meriin, A.B., Zhang, X., He, X., Newnam, G.P., Chernoff, Y.O. and Sherman, M.Y. (2002) Huntingtin toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1. Journal of Cell Biology 157: 997-1004. (Abstract) (Highlight)

Borchsenius, A.S., Wegrzyn, R.D., Newnam, G.P., Inge-Vechtomov, S.G. and Chernoff, Y.O. (2001) Yeast prion protein derivative defective in aggregate shearing and production of new seeds. The EMBO Journal 20: 6683-6691. (Abstract) (Highlight)

Jensen, M.A., True, H.L., Chernoff, Y.O. and Lindquist, S. (2001) Molecular population genetics and evolution of a prion-like protein in Saccharomyces cerevisiae. Genetics 159: 527-535.

Wegrzyn, R.D., Bapat, K., Newnam, G.P., Zink, A.D. and Chernoff, Y.O. (2001) Mechanism of prion loss after Hsp104 inactivation in yeast. Molecular and Cellular Biology 21: 4656-4669. (Abstract) (Highlight)

Chernoff, Y.O. (2001) Mutation processes at the protein level: is Lamarck back? Reviews in Mutation Research 488: 39-64. (Abstract)

Kulikov, V.V., Derkatch, I.L., Noskov, V.N., Tarunina, O.V., Chernoff, Y.O., Rogozin, I.B. and Pavlov, Y.I. (2001) Mutagenic specificity of the base analog 6-N-hydroxylaminopurine in the LYS2 gene of yeast Saccharomyces cerevisiae. Mutation Research 473: 151-161.

Velichutina, I.V., Hong, J.Y., Mesecar, A.D., Chernoff, Y.O. and Liebman, S.W. (2001) Genetic interaction between yeast Saccharomyces cerevisiae release factors and the decoding region of the 18S rRNA. Journal of Molecular Biology 305: 715-727.

Bailleul-Winslett, P.A., Newnam, G.P., Wegrzyn, R.D. and Chernoff, Y.O. (2000) An anti-prion effect of the anticytoskeletal drug latrunculin A in yeast. Gene Expression 9: 145-154. (Abstract)

Chernoff, Y.O., Galkin, A.P., Lewitin, E., Chernova, T.A., Newnam, G.P. and Belenkiy, S.M. (2000) Evolutionary conservation of prion-forming abilities of the yeast Sup35 protein. Molecular Microbiology , 35: 865-876. (Abstract)

Chernoff, Y.O., Newnam, G.P., Kumar, J., Allen, K. and Zink, A.D. (1999) Evidence for a "protein mutator" in yeast: Role of the Hsp70-related chaperone Ssb in formation, stability and toxicity of the [PSI] prion. Molecular and  Cellular Biology , 19: 8103-8112. (Article)

Bailleul, P.A., Newnam, G.P., Steenbergen, J.N. and Chernoff, Y.O. (1999) Genetic study of interactions between the cytoskeletal assembly protein Sla1 and prion-forming domain of the release factor Sup35 (eRF3) in Saccharomyces cerevisiae. Genetics , 153: 81-94. (Article)

Newnam, G.P., Wegrzyn, R.D., Lindquist, S.L., and Chernoff, Y.O. (1999) Antagonistic interactions between yeast chaperones Hsp104 and Hsp70. Molecular and Cellular Biology , 19: 1325-1333. (Article)

Wickner, R.B. and Chernoff, Y.O. (1999) Prions of fungi: [URE3], [PSI] and [Het-s] discovered as heritable traits. In: Prion Biology and Diseases (Prusiner, S.B., ed.). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, pp. 229-272.

Burck, C.L., Chernoff, Y.O., Liu, R., Farabaugh, P.J. and Liebman, S.W. (1999) Translational suppressors and antisuppressors alter the efficiency of the Ty1 translational frameshift. RNA , 5: 1451-1457.

Chernoff, Y.O. (1999) A black spot of the modern biology. (Book Review: Prions. Molecular and Cellular Biology) Trends in Genetics , 15: 336.

Derkatch, I.L., Bradley, M.E., Zhou, P., Chernoff, Y.O. and Liebman, S.W. (1997) Genetic and environmental factors affecting the de novo appearance of the [PSI+ ] prion in Saccharomyces cerevisiae. Genetics , 147: 507-519.

Derkatch, I.L., Chernoff, Y.O., Kushnirov, V.V.,Inge-Vechtomov, S.G., and Liebman, S.W. (1996) Genesis and variability of [PSI] prion factors in Saccharomyces cerevisiae. Genetics , 144: 1375-1386.

Chernoff, Y. O., Newnam, G. and Liebman, S. W. (1996) The translational function of nucleotide C1054 in the small subunit ribosomal RNA is conserved throughout evolution: Genetic evidence in yeast. Proceedings of the National Academy of Sciences of USA , 93: 2517-2522.

Lindquist, S., Patino, M.M., Chernoff, Y.O., Kowal, A.S., Singer, M.A., Lee, K.-H., Blake, T., and Liebman, S.W. (1995) The role of Hsp104 in stress tolerance and [PSI+ ] propagation in Saccharomyces cerevisiae. In: Protein Kinesis. Cold Spring Harbor Symp. Quant. Biol. , 60: 451-460.

Chernoff, Y.O., Liebman, S.W., Patino, M. and Lindquist, S.L. (1995) Response from Chernoff et al. [Re: R. B. Wickner, Prions of yeast and heat-shock protein 104: "coprion" and cure]. Trends in Microbiology , 3: 369.

Chernoff, Y.O., Lindquist, S.L., Ono, B., Inge-Vechtomov, S.G. and Liebman, S.W. (1995) Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [PSI+ ]. Science , 268: 880-884.  (Abstract)

Liebman, S.W., Chernoff, Y.O. and Liu, R. (1995) The accuracy center of a eukaryotic ribosome. Biochemistry and Cell Biology , 73: 1141-1149.

Chernoff, Y.O., Vincent, A. and Liebman, S.W. (1994) Mutations in eukaryotic 18S ribosomal RNA affect translational fidelity and resistance to aminoglycoside antibiotics. The EMBO Journal , 13: 906-913.

Chernoff, Y.O., Derkach, I.L. and Inge-Vechtomov, S.G. (1993) Multicopy SUP35 gene induces de-novo appearance of psi-like factors in the yeast Saccharomyces cerevisiae. Current Genetics , 24: 268-270.

Ter-Avanesyan, M.D., Kushnirov, V.V., Dagkesamanskaya, A.R., Didichenko, S.A., Chernoff, Y.O., Inge-Vechtomov, S.G. and Smirnov, V.N. (1993) Deletion analysis of the SUP35 gene of the yeast Saccharomyces cerevisiae reveals two non-overlapping functional regions in the encoded protein. Molecular Microbiology , 7: 683-692.

Hiep, T.T., Kulikov, V.N., Noskov, V.N., Sizonenko, G.I., Chernoff, Y.O. and Pavlov, Y.I. (1993) The 5-aminoimidazole ribonucleotide-carboxylase structural gene of the methylotrophic yeast Pichia methanolica: Cloning, sequencing and homology analysis. Yeast , 9: 1251-1258.

Chernoff, Y.O. and Ono, B. (1993) Dosage-dependent modifiers of psi-dependent omnipotent suppression in yeast. In: Protein Synthesis and Targeting in Yeast (Brown, A.J.P. et al., eds.), NATO ASI, vol. H71: pp. 101-110.

Chernoff, Y.O., Ptyushkina, M.V., Samsonova, M.G., Sizonencko, G.I., Pavlov, Y.I., Ter-Avanesyan, M.D. and Inge-Vechtomov, S.G. (1992) Conservative system for dosage-dependent modulation of translational fidelity in eukaryotes . Biochimie , 74: 455-461.

Chernoff, Y.O ., Inge-Vechtomov, S.G., Derkach, I.L., Ptyushkina, M.V., Tarunina, O.V., Dagkesamanskaya, A.R. and Ter-Avanesyan, M.D. (1992) Dosage-dependent translational suppression in yeast Saccharomyces cerevisiae. Yeast , 8: 489-499.

Ono, B., Chernoff, Y.O., Ishino-Arao, Y., Yamagishi, N., Shinoda, S. and Inge-Vechtomov, S.G. (1991) Interactions between chromosomal omnipotent suppressors and extrachromosomal effectors in Saccharomyces cerevisiae. Current Genetics , 19: 243-248.

Kushnirov, V.V., Ter-Avanesyan, M.D., Didichenko, S.A., Smirnov, V.N., Chernoff, Y.O., Derkach, I.L., Novikova, O.N., Inge-Vechtomov, S.G., Neistat, M.A. and Tolstorukov, I.I. (1990) Divergence and conservation of SUP2 (SUP35) gene of yeasts Pichia pinus and Saccharomyces cerevisiae. Yeast , 6: 461-472.

Sizonenko, G.I., Chernoff, Y.O., Kulikov, V.N., Karpova, T.S., Kashkin, P.K., Pavlov, Y.I., Bechtereva, T.A., Sakharova, Y.V., Tikhodeyev, O.N. and Inge-Vechtomov, S.G. (1990) A new class of ochre-suppressors in yeast Saccharomyces: mutation in glutamine tRNA gene. Doklady Akad. nauk SSSR (Biol. Sci.) , 310: 1480-1484 (in Russian).

Kushnirov, V.V., Ter-Avanesyan, M.D., Dagkesamanskaya, A.R., Chernoff, Y.O., Inge-Vechtomov, S.G. and Smirnov, V.N. (1990) Deletion analysis of SUP2 gene of yeast Saccharomyces cerevisiae. Molekularnaya Biologia , 24: 1037-1041 (in Russian with English summary).

Kushnirov, V.V., Ter-Avanesyan, M.D., Smirnov, V.N., Chernoff, Y.O., Derkach, I.L., Novikova, O.N., Inge-Vechtomov, S.G., Neistat, M.A. and Tolstorukov, I.I. (1990) Comparative analysis of SUP2 genes structure of yeasts Pichia pinus and Saccharomyces cerevisiae. Molekularnaya Biologia , 24: 1024-1036 (in Russian with English summary).

Noskov, V.N., Tarutina, M.G., Chernoff, Y.O., Gordenin, D.A. and Pavlov, Y.I. (1990) Genetic analysis of spontaneous and 6-N-hydroxylamino-purine- or propiolactone-induced Adp + mutants in yeastSaccharomyces. Genetika, 26: 1169-1177 (in Russian with English summary).

Noskov, V.N., Tarutina, M.G., Pavlov, Y.I., Kulickov, V.N., Trofimova, M.V., Gorbacheva, A.V., Chernoff, Y.O., Sasnauskas,  K.V., Neistat, M.A., Tolstorukov, I.I. and Gordenin, D.A. (1990) Elaboration of intragenic mapping system for molecular genetic analysis of mutations in LYS2 gene of yeast Saccharomyces. Genetika , 26: 1161-1168 (in Russian with English summary).

Inge-Vechtomov, S.G., Kushnirov, V.V., Ter-Avanesyan, M.D. and Chernoff, Y.O. (1990) Homology and divergence of genes controlling the fidelity of protein synthesis. Trudy Biol. Inst. (Proceedings of the Biological Institute) (Seravin, L.N. et al., eds.), 41: 58-80 (in Russian).

Gordenin, D.A., Trofimova, M.V., Shaburova, O.N., Pavlov, Y.I., Chernoff, Y.O., Chekuolene, Y.V., Proscyavichus, Y.Y., Sasnauskas, K.V. and Janulaitis, A.A. (1988) Precise excision of bacterial transposon Tn5 in yeast. Molecular and General Genetics , 213: 388-393.

Chernoff, Y.O., Derkach, I.L., Tikhomirova, V.L., Dagkesamanskaya, A.R., Ter-Avanesyan, M.D. and Inge-Vechtomov, S.G. (1988) Nonsense-suppression by amplification of translation protein factor gene. Doklady Akad. nauk SSSR (Biol. Sci.) , 301: 1227-1229 (in Russian).

Pavlov, Y.I., Noskov, V.N., Chernoff, Y.O. and Gordenin, D.A. (1988) The study of mutability of LYS2 gene in diploid yeast Saccharomyces. II. Mutants induced by 6-N-hydroxylaminopurine and propiolactone. Genetika , 24: 1752-1760 (in Russian with English summary).

Chernoff, Y.O. and Gordenin, D.A. (1987) Phenotypic expression of the yeast transposon insertion in the LYS2 gene and of deletions resulting from imprecise excision of the transposon. Genetika , 23: 30-40 (in Russian with English summary).

Chernoff, Y.O. and Gordenin, D.A. (1987) Homologous recombination in yeast. Uspekhi sovremennoi genetiki (Advances in Current Genetics) , 14: 3-47 (in Russian).

Chernoff, Y.O., Kidgotko, O.V., Demberilijn, O. and Gordenin, D.A. (1986) Mapping of mutations in LYS2 gene of yeast Saccharomyces cerevisiae. In: Issledovania po genetike (Researches in Genetics) . (Inge-Vechtomov, S.G., ed.) Leningrad University, vol. 10: pp. 92-104 (in Russian with English summary).

Chernoff, Y.O., Gordenin, D.A., Soldatov, S.P. and Glazer, V.M. (1985) The study of mutability of LYS2 gene in diploid yeast Saccharomyces. I. The origin of spontaneous, X-ray and ultraviolet-induced mutants. Genetika, 21: 564-573 (in Russian with English summary).

Chernoff, Y.O., Kidgotko, O.V., Demberelijn, O., Luchnikova, I.L., Soldatov, S.P., Glazer, V.M. and Gordenin, D.A. (1984) Mitotic intragenic recombination in the yeast Saccharomyces: Marker-effects on conversion and reciprocity of recombination. Current Genetics, 9: 31-37.

Gordenin, D.A. and Chernoff, Y.O. (1984) A new marker-effect on intragenic recombination in the yeast Saccharomyces. Doklady Akad. nauk SSSR (Biol. Sci. ), 274: 716-719 (in Russian).