Dammer EB, Sewer MB. Phosphorylation of CtBP1 by PKA modulates induction of CYP17 by stimulating partnering of CtBP1 and 2. J Biol Chem. Epub 2008 Jan 9.

Sewer MB, Dammer EB, Jagarlapudi S. Transcriptional regulation of adrenocortical steroidogenic gene expression. Drug Metab Rev. 2007;39(2-3):371-88. Review.

Li D, Urs AN, Allegood J, Leon A, Merrill AH Jr, Sewer MB. Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17. Mol Cell Biol. 2007 Oct;27(19):6669-85. Epub 2007 Jul 30.

Urs AN, Dammer E, Kelly S, Wang E, Merrill AH Jr, Sewer MB. Steroidogenic factor-1 is a sphingolipid binding protein. Mol Cell Endocrinol. 2007 Feb;265-266:174-8. Epub 2006 Dec 29.

Dammer EB, Leon A, Sewer MB. Coregulator Exchange and Sphingosine-Sensitive Cooperativity of Steroidogenic Factor-1, GCN5, p54, and p160 Coactivators Regulate cAMP-Dependent CYP17 Transcription Rate. Molecular Endocrinology 21(2):415-38, 2007. Epub 2006 Nov 22.

Urs AN, Dammer EB, Sewer MB. Sphingosine Regulates the Transcription of CYP17 by Binding to Steroidogenic Factor-1. Endocrinology 147(11):5249-58, 2006. Epub 2006 Aug 3.

Ozbay T, Rowan A, Leon A, Patel P, Sewer MB. cAMP-Dependent Sphingosine-1-Phosphate Biosynthesis Induces Human CYP17 Gene Transcription by Activating Cleavage of Sterol Regulatory Element Binding Protein 1. Endocrinology 147(3):1427-37, 2006. Epub 2005 Nov 23.

Ozbay T, Merrill AH Jr, Sewer MB. ACTH regulates steroidogenic gene expression and cortisol biosynthesis in the human adrenal cortex via sphingolipid metabolism. Endocrine Research 30(4): 787-94, 2004.

Sewer MB and Waterman MR. ACTH Modulation of Transcription Factors Responsible for Steroid Hydroxylase Gene Expression in the Adrenal Cortex. Microscopy and Research Techniques 61(3): 300-7, 2003.

Sewer MB and Waterman MR. CAMP-dependent protein kinase enhances CYP17 transcription via MKP-1 activation in H295R human adrenocortical cells. Journal of Biological Chemistry 278(10): 8106-11, 2003.

Sewer MB and Waterman MR. Transcriptional Complexes at the CYP17 CRS. Endocrine Research 28(4): 551-8, 2002.

Sewer MB and Waterman MR. cAMP-Dependent Transcription of Steroidogenic Genes in the Human Adrenal Cortex Requires a Phosphatase in Addition to PKA. Journal of Molecular Endocrinology 29(1): 163-174, 2002.

Sewer MB and Waterman MR. ACTH/cAMP-Mediated transcription of the human CYP17 gene in the adrenal cortex is dependent on phosphatase activity. Endocrinology 143(5): 1769-1777, 2002.

Sewer MB, Nguyen VQ, Huang C-J, Tucker PW, Kagawa N and Waterman MR. Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation between p54nrb/Nono, PSF, and SF-1, a complex which also participates in repression of transcription. Endocrinology 143(4):1280-1290, 2002.

Sewer MB and Waterman MR. Insights into the transcriptional regulation of steroidogenic enzymes and StAR. Reviews in Endocrine & Metabolic Disorders 2(3): 269-274, 2001.

Mitchell SR, Sewer MB, Kardar SS, and Morgan ET. Characterization of CYP4A induction in rat liver by inflammatory stimuli: dependence on sex, strain, and inflammation-evoked hypophagia. Drug Metabolism and Disposition 29(1):17-22, 2001.

Barclay TB, Peters JM, Sewer MB, Ferrari L, Gonzalez FJ, and Morgan ET. Modulation of Cytochrome P450 Gene Expression in Endotoxemic Mice is Tissue-Specific and PPARa-dependent. Journal of Pharmacology and Experimental Therapeutics 290:1250-1257, 1999.

Iber H, Sewer MB, Barclay TB, Mitchell SR, Li T, Morgan ET. Modulation of drug metabolism in infectious and inflammatory diseases. Drug Metabolism Reviews 31:29-41, 1999.

Morgan ET, Sewer MB, Iber H, Gonzalez FJ, Lee YH, Tukey RH, Okino S, Vu T, Chen YH, Sidhu, JS, Omiecinski CJ. Physiological and Pathophysiological Regulation of Cytochrome P450. Drug Metabolism and Disposition 26(12):1232-1240, 1998.

Sewer MB and Morgan ET. Down-Regulation of the Expression of Three Major Rat Liver Cytochrome P450s by Endotoxin In Vivo Occurs Independently of Nitric Oxide Production. Journal of Pharmacology and Experimental Therapeutics 287(1):352-358, 1998.

Sewer MB, Barclay TB, Morgan ET. Down-Regulation of Cytochrome P450 mRNAs and proteins in Mice Lacking a Functional NOS2 gene. Molecular Pharmacology. 54(2):273-279, 1998.

Sewer MB and Morgan ET. Nitric Oxide Independent Suppression of P-450 2C11 Expression by Interleukin-1b and Endotoxin in Primary Rat Hepatocytes. Biochemical Pharmacology 54(6):729-37, 1997.

Iber H, Chen Q, Sewer M, and Morgan ET. Regulation of Hepatic Cytochrome P450 2C11 by Glucocorticoids. Archives of Biochemistry and Biophysics 45(2):305-10, 1997.

Sewer MB, Koop DR, and Morgan ET. Differential Inductive and Suppressive Effects of Endotoxin and Particulate Irritants on Hepatic and Renal Cytochrome P-450 Expression. Journal of Pharmacology and Experimental Therapeutics 280(3): 1445-1454, 1997.

Sewer MB, Koop DR, and Morgan ET. Endotoxemia in Rats is Associated with Induction of the P-450 4A Subfamily and Suppression of Several other Forms of Cytochrome P-450. Drug Metabolism and Disposition 24(4):401-7, 199, 1996.